Edgardo Moreno Robles

Researchers

  • Senior Professor, Veterinary Medicine School, National University, Heredia, Costa Rica
  • Sabbatical II: Planck Institute for Infectious Diseases, Germany 2002-2003
  • Sabbatical I: Center for Immunology, Luminy, Marseille (CIML), France 1987-1988
  • Postdoctoral training: Max Planck Institute for Immunobiology, Germany 1985-1986
  • Ph.D. Veterinary Sciences, University of Wisconsin-Madison, USA, 1979
  • M.Sc. in Microbiology, University of Costa Rica, 1976
  • Lic. Microbiology and Clinical Chemistry, University of Costa Rica (UCR), 1975

Edgardo Moreno Robles

His researches focus on the understanding of immunology, pathology, and epidemiology of brucellosis. His studies have elucidated the virulence and adaptation mechanisms that intervene in the intracellular life of Brucella, as well as the immunity and diagnosis of the disease, and the evolution and taxonomy of the Brucella genus. 

From 1991 to 1999 Dr. Moreno was the dean of the Postgraduate Program in Biomedical Sciences between the Central American universities and the Karolinska Institute in Sweden. 

From 1999 to 2003 Dr. Moreno was the first coordinator of the Network for Research and Training in Tropical Diseases in Central America (NeTropica). 

He has been a consultant and adviser for the Swedish Development Agency, the Organization for Tropical Studies, the Inter-American Development Bank, the National Institutes of Health (NIH) in the USA and Caprion Pharmaceuticals. He was a visiting professor at the Louisiana University from 1997 to 2000. Dr. Moreno was the General Health Coordinator of the Ibero-American Programme for the Development of Science and Technology, CYTED (2006-2008), and the director of the Tropical Disease Research Program, PIET (1990-2005). 

He is the vice-president of the National Academy of Sciences in Costa Rica, and a researcher at the Clodomiro Picado Institute, UCR. He has received grants from more than 30 sources, has been tutor for 38 graduate and postgraduate students, and has participated in many courses in public universities in Central America. 

He has 134 scientific publications and 41 essays dedicated to the promotion of knowledge. 

Publicaciones representativas de sus intereses de investigación

  • Chacón-Díaz, C., Muñoz-Rodríguez, M., Barquero-Calvo, E., Guzmán-Verri, C., Chaves-Olarte, E., Grilló, M. J., Moreno, E. (2011). The use of green fluorescent protein as a marker for Brucella vaccines. Vaccine, 29(3), 577-582. doi: 10.1016/j.vaccine.2010.09.109
  • Martirosyan, A., Moreno, E., Gorvel, J. P. (2011). An evolutionary strategy for a stealthy intracellular Brucella pathogen. Immunol Rev, 240(1), 211-234. doi: 10.1111/j.1600-065X.2010.00982.x
  • Guzmán-Verri, C., González-Barrientos, R., Hernández-Mora, G., Morales, J. A., Baquero-Calvo, E., Chaves-Olarte, E., & Moreno, E. (2012). Brucella ceti and brucellosis in cetaceans. Front CellInfect Microbiol, 2-3. doi:10.3389/fcimb.2012.00003
  • Conde-Álvarez, R., Arce-Gorvel, V., Iriarte, M., Manček-Keber, M., Barquero-Calvo, E., Palacios-Chaves, L., … Moreno, E., Moriyón, I., Gorvel. J. P. (2012). The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. Plos Pathog, 8(5), e1002675. doi: 10.1371/journal.ppat.1002675
  • Grilló, M. J., Blasco, J. M., Gorvel, J. P., Moriyón, I., Moreno, E. (2012). What have we learned from brucellosis in the mouse model? Vet Res, 43,29. doi: 10.1186/1297-9716-43-29.
  • Martirosyan, A., Pérez-Gutierrez, C., Banchereau, R., Dutartre, H., Lecine, P., Dullaers, … Moreno, E., Moriyón, I., Klechevsky, E., Banchereau, J., Oh, S., Gorvel. J. P. (2012). Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells. PLoS Pathog, 8(11), e1002983. doi: 10.1371/journal.ppat.1002983
  • Barquero-Calvo, E., Martirosyan, A., Ordoñez-Rueda, D., Arce-Gorvel, V., Alfaro-Alarcón, A., Lepidi, H., Malissen, B., Malissen, M., Gorvel, J. P., Moreno, E. (2013). Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus. Plos Pathog, 9(2), e1003167. doi: 10.1371/journal.ppat.1003167
  • Moreno, E. (2014). Retrospective and prospective perspectives on zoonotic brucellosis. Front Microbiol, 5, 213. doi: 10.3389/fmicb.2014.00213.
  • Barquero-Calvo, E., Mora-Cartín, R., Arce-Gorvel, V., de Diego, J. L., Chacón-Díaz, C., Chaves-Olarte, E., …Moreno, E. (2015). Brucella abortus induces the premature death of human neutrophils through the action of its lipopolysaccharide. Plos Pathog, 11(5), e1004853. doi: 10.1371/journal.ppat.1004853
  • Chacón-Díaz, C., Altamirano-Silva, P., González-Espinoza, G., Medina, M. C., Alfaro-Alarcón, A., Bouza-Mora, L., … Moreno, E. & Chaves-Olarte, E. (2015). Brucella canis is an intracellular pathogen inducing a lower proinflammatory response than smooth zoonotic counterparts. Infect Immun, 83(12), 4861-4870. doi:10.1128/IAI.00995-15
  • Mora-Cartín, R., Chacón-Díaz, C., Gutiérrez-Jiménez, C., Gurdián-Murillo, S., Lomonte, B., Chaves-Olarte, E., Barquero-Calvo, E., Moreno, E. (2016). N-Formyl-perosamine surface homopolysaccharides hinder the recognition of Brucella abortus by mouse neutrophils. Infect Immun, 84(6), 1712-1721. doi: 10.1128/IAI.00137-16