María Herrera Vega


  • Researcher of the Technological Development Section, Industrial Division, Clodomiro Picado Institute, University of Costa Rica.
  • M.Sc. in Chemistry, University of Costa Rica, 2012.
  • B.S. Chemistry, University of Costa Rica, 2004.

María Herrera’s researches focus on the biochemical, toxicological, and proteomic characterization of snake venoms, the development, formulation, and characterization of antivenoms, the development of lyophilization processes for pharmaceutical proteins, development and implementation of analysis methods and stability tests for proteins, as well as the research and development of new products, like antitoxins, vaccines, and other immunobiologicals.

Publicaciones representativas de sus intereses de investigación

  • Herrera, M., León, G., Segura, A., Meneses, F., Lomonte, B., Chippaux, J. P., & Gutiérrez, J. M. (2005). Factors associated with adverse reactions induced by whole IgG preparations: comparison between horse, sheep and camel IgGs. Toxicon, 46(7), 775-781.
  • Herrera, M., Meneses, F., León, G., Gutiérrez, J. M. (2009). Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production. Biologicals, 37(4), 230-234. doi: 10.1016/j.biologicals.2009.02.020
  • Segura, A., Villalta, M., Herrera, M., León, G., Harrison, R., Durfa, N., …Gutiérrez, J. M. (2010). Preclinical assessment of the efficacy of a new antivenom (EchiTab-plus-ICP®) for the treatment of viperid snakebite envenomings in Sub-saharan Africa. Toxicon, 55(2-3), 369-74. doi: 10.1016/j.toxicon.2009.08.010
  • Herrera, M., Fernández, J., Vargas, M., Villalta, M., Segura, A., León, G., …Gutiérrez, J. M. (2012). Comparative proteomic analysis of the venom of the snake taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity. J Proteomics, 75(7), 2128-2140. doi: 10.1016/j.jprot.2012.01.006
  • Segura, A., Vargas, M., León, G., Villalta, M., Herrera, M., Angulo, Y. (2012). Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método. Solicitud de patente Publication Number: WO 2012/136172 A1. Recuperado de
  • Olmedo, H.; Herrera, M.; Rojas, L. Villalta, M., Vargas, M., Leiguez, E., … Montero, M. (2013). Comparison of the adjuvant activity of aluminun hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom. J Immunotoxicol, 11(1), 44-49. doi: 10.3109/1547691X.2013.772267