Yamileth Angulo Ugalde


  • Senior Professor, Clodomiro Picado Institute, Faculty of Microbiology.
  • Ph.D. University of Costa Rica.
  • M.Sc. University of Costa Rica.
  • Lic. Microbiology and Clinical Chemistry, University of Costa Rica

Yamileth Angulo's researches focus on the biochemical characterization and the mechanism of action of proteins in snake venoms, like phospholipase A2 which is responsible for the myotoxic effect in envenomings caused by snakebites from the Viperidae family, as well as the disintegrins found in snake venoms. Another research subject has been the search and biochemical characterization of phospholipase-inhibitor molecules, both natural and synthetic. She is part of a group of researchers from the Clodomiro Picado Institute whose most recent research topics is the proteomics analysis of venoms in Costa Rica.

Furthermore, she was the director of the Biochemistry Department of the School of Medicine, and the deputy director of the School of Medicine. In later years she was the director of the Clodomiro Picado Institute from 2004 to 2012, and today she is a member of the University Council of the University of Costa Rica.

Publicaciones representativas de sus intereses de investigación

  • Herrera, M., Fernández, J., Vargas, M., Villalta, M., Segura, A., León, G., Angulo, Y., Paiva, O., Matainaho, T., Jensen, S., Winkel, K., Calvete, J. J., Williams, D., & Gutiérrez, J. J. (2012). Comparative proteomic analysis of the venons of the snake taipan Oxyuranus scutellatus from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venos toxicity. Journal of Proteomics, 75, 2128-2140.
  • Lomonte, B., Rey-Suárez, P., Tsai, W. C., Angulo, Y., Sasa, M., Gutiérrez, J. M., & Calvete, J. J. (2012). Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophyomegas and Cerrophidion godmani from Costa Rica: Toxicological and Taxonomical insights. Journal of proteomics, 75,1675-1689.
  • Lomonte, B., Tsai, W. C., Bonilla, F., Solórzano, A., Solano, G., Angulo, Y., Gutiérrez, J. M., & Calvete, J. J. (2012). Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supaciliaris from Costa Rica. Toxicon, 59, 592-599.
  • Vargas, M., Segura, Á., Herrera, M., Villalta, M., Angulo, Y., Burnouf, T., Gutiérrez, J. M., & León, G. (2012). Purification of IgG and albumin from human plasma by aqueous two phase system fractionation. Biotechnology Progress, 28,1005-1011.
  • Villalta, M., Pla, D., Lin Yang, S., Sanz, L., Segura, A., Vargas, M., Yu Chen, P., Herrera, M., Estrada, R., Cheng, Y., F, Lee, C. D., Cerdas. M., Jiang, J. R., Angulo, Y., León, G., Calvete, J. J., & Gutiérrez, J. M. (2012). Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses. Journal of Proteomics, 75, 5628-5645.
  • Durban, J., Pérez, A., Sanz, L., Sasa, M., Gómez, A., Angulo, Y., Gutiérrez, J. M., & Calvete, J. J. (2013). Integrated "omics" profiling hints to miRNAs as modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus. BMC Genomics, 14, 234. doi: 10.1186/1471-2164-14-234
  • Gutiérrez, J. M., Tsai, W. C., Pla, D., Solano, G., Lomonte, B., Sanz, L., Angulo, Y., & Calvete, J. J. (2013). Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and in vivo neutralization assays. Toxicon, 64, 60-69. doi: 10.1016/j.toxicon.2012.12.024