Julián Fernández Ulate


  • Visiting Professor, Clodomiro Picado Institute, Faculty of Microbiology.
  • Ph.D. in Biosciences and Biotechnologies, Padua University, Italy (Università degli studi di Padova, 2014).
  • M.Sc. of the Postgraduate Program in Microbiology, Parasitology and Clinical Chemistry, University of Costa Rica, 2010.
  • Lic. in Microbiology and Clinical Chemistry, University of Costa Rica, 2007.

Julián Fernández studies the proteomic composition of snake envenomings and the mechanisms of action of the toxins in these venoms. He studied the proteomic composition of the venoms of at least 7 species of snakes, as well as the isolation, sequencing, and characterization of at least 3 previously unknown proteins from different venoms of snakes in Costa Rica. Today he studies the mechanism of action of myotoxins in snake venoms, as well as the characterization and study of important toxins in snake venoms. 

Publicaciones representativas de sus intereses de investigación

  • Fernández, J., Gutiérrez, J. M., Angulo, Y., Sanz, L., Juárez, P., Calvete, J. J., Lomonte, B. (2010). Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization. Biochimie, 92(3), 273-83. doi: 10.1016/j.biochi.2009.12.006
  • Fernández, J., Lomonte, B., Sanz, L., Angulo, Y., Gutiérrez, J. M., Calvete, J. J. (2010). Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose. J Proteome Res, 9(8), 4234-41. doi: 10.1021/pr100545d
  • Fernández, J., Alape-Girón, A., Angulo, Y., Sanz, L., Gutiérrez, J. M., Calvete, J.J., Lomonte, B. (2011). Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae). J Proteome Res, 10(4), 1816-27.
  • Fernández, J., Caccin, P., Koster, G., Lomonte, B., Gutiérrez, J. M., Montecucco, C., Postle, A. D. (2013). Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A₂ myotoxins--distinct mechanisms of action. FEBS J, 280(16), 3878-86. doi: 10.1111/febs.12386
  • Lomonte, B., Fernández, J., Sanz, L., Angulo, Y., Sasa, M., Gutiérrez, J. M., Calvete, J. J. (2014). Venomous snakes of Costa Rica: Biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics. J Proteomics, 105, 323-339. doi: 10.1016/j.jprot.2014.02.020
  • Fernández, J., Vargas-Vargas, N., Pla, D., Sasa, M., Rey-Suárez, P., Sanz, L., Gutiérrez, J. M., Calvete, J. J., Lomonte, B. (2015). Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids. Toxicon,107(Pt B), 217-33. doi: 10.1016/j.toxicon.2015.08.016