José María Gutiérrez Gutiérrez


  • Senior Professor, Clodomiro Picado Institute, Faculty of Microbiology.
  • Lic. in Microbiology and Clinical Chemistry, University of Costa Rica (1977)
  • Ph.D. in Physiological Science, Oklahoma State University, USA. (1984)
  • Sabbatical at the Instituto Butantan, Sao Paulo, Brazil (1996 and 2000).

José María Gutierrez has a Licentiate degree in Microbiology and Clinical Chemistry, and a Doctorate degree in Physiological Sciences. He is a member of the Academic Division in the Clodomiro Picado Institute of the University of Costa Rica, and is a senior professor at the Faculty of Microbiology of the same university, where he teaches graduate and postgraduate classes in Immunology, Research Methods, Biochemistry, and Cell Pathology.

His areas of research include biochemistry, immunology, and experimental pathology of snake venoms, particularly the study of the mechanism of action of toxins that cause local tissue lesions in envenomings from snakes of the Viperidae family. Furthermore, he participates in projects to improve antivenoms used to treat snakebite envenomings; he studies the neutralizing ability of antivenoms from different regions of the world, the development of new antivenoms for countries that lack these products, and the search of new inhibiting agents for venom toxins. He is also interested in subjects related to scientific-technological development, science history in Costa Rica, and social implications of the scientific work.

He has been the director, deputy director, and coordinator of the Academic Division in the Clodomiro Picado Institute, and the director of the Postgraduate Program in Microbiology, Parasitology, and Clinical Chemistry, as well as the coordinator of the Postgraduate Program in Central American Biomedical Sciences of the Karolinska Institute. Today he coordinates the international cooperation activities of the Clodomiro Picado Institute. He has worked as a consultant for the World Health Organization in the subject of antivenoms. 

Publicaciones representativas de sus intereses de investigación

  • Rucavado, A., Escalante, T., Shannon, J. D., Ayala-Castro, C. N., Villalta, M., Gutiérrez, J. M., Fox, J. W. (2012). Efficacy of IgG and F(ab')2 antivenoms to neutralize snake venom-induced local tissue damage as assessed by the proteomic analysis of wound exudate. J Proteome Res, 11(1), 292-305.
  • Otero-Patiño, R., Segura, A., Herrera, M., Angulo, Y., León, G., Gutiérrez, J. M., … Ortiz, R. (2012). Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab’)2] antivenoms, in Bothrops asper bites in Colombia. Toxicon. 59(2), 344-355. doi: 10.1016/j.toxicon.2011.11.017
  • Herrera, M., Fernández, J., Vargas, M., Villalta, M., Segura, A., León, G., …Gutiérrez, J. M. (2012). Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity. J Proteomics, 75(7), 2128-2140. doi: 10.1016/j.jprot.2012.01.006
  • Pla, D., Gutiérrez, J. M., Calvete, J. J. (2012).Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols. Toxicon, 60(4), 688-699. doi: 10.1016/j.toxicon.2012.04.342
  • Villalta, M., Pla, D., Yang, S. L., Sanz, L., Segura, A., Vargas, M., Chen, P.Y., Herrera, M., Estrada, R., Cheng, Y. F., Lee, C. D., Cerdas, M., Jiang, J. R., Angulo, Y., León, G., Calvete, J. J. & Gutiérrez, J. M. (2012). Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses. J Proteomics, 75(18), 5628-5645. doi: 10.1016/j.jprot.2012.08.008
  • Herrera, C., Rucavado, A., Warrell, D. A., & Gutiérrez, J. M. (2013).Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model. Toxicon, 63, 9-31. doi: 10.1016/j.toxicon.2012.10.023
  • Gutiérrez, J. M., Solano, G., Pla, D., Herrera, M., Segura, A., Villalta, M., …León, G. (2013). Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics. Toxicon, 69, 168-179. doi: 10.1016/j.toxicon.2012.11.016
  • Castro, E.N., Lomonte, B., Gutiérrez, M. C., Alagón, A., & Gutiérrez, J. M. (2013). Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies. J Proteomics, 87,103-121. doi: 10.1016/j.jprot.2013.05.024
  • Gutiérrez, J. M., Warrell, D. A., Williams, D. J., Jensen, S., Brown, N., Calvete, J. J. & Harrison, R. (2013). The need for full integration of snakebite envenoming within a global strategy to combat the neglected tropical diseases: The way forward. PLoS Negl Trop Dis, 7(6), e2162. doi: 10.1371/journal.pntd.0002162